| Sat 30/07/22 | FC Isle of Man v Lower Breck | 0-1 | | |  | | |
| Thu 04/08/22 | Lower Breck v Vauxhall Motors | 1-2 | | | | | |
| Sat 06/08/22 | Lower Breck v Penistone Church | 0-2 | | | | | |
| Sat 13/08/22 | Avro v Lower Breck | 1-0 | | | | | |
| Thu 18/08/22 | Lower Breck v Burscough | 2-0 | | | | | |
| Sat 20/08/22 | Lower Breck v Irlam * | 0-2 | | | | | |
| Tue 23/08/22 | Northwich Victoria v Lower Breck | 2-0 | | | | | |
| Sat 27/08/22 | Lower Breck v Daisy Hill | 3-3 | | | | | |
| Mon 29/08/22 | Lower Breck v Wythenshawe Town | - | | | | | |
| Sat 17/09/22 | Lower Breck v Kendal Town * | 1-0 | | | | | |
| Sat 01/10/22 | Longridge Town v Lower Breck | 5-1 | | | | | |
| Tue 04/10/22 | West Didsbury & Chorlton v Lower Breck | 1-4 | | | | | |
| Sat 08/10/22 | Lower Breck v Northwich Victoria | 1-3 | | | | | |
| Sat 15/10/22 | Litherland REMYCA v Lower Breck | 0-4 | | | | | |
| Thu 20/10/22 | Lower Breck v AFC Liverpool | 2-0 | | | | | |
| Sat 22/10/22 | Congleton Town v Lower Breck | 2-1 | | | | | |
| Sat 29/10/22 | Lower Breck v Barnoldswick Town | 1-0 | | | | | |
| Thu 03/11/22 | Lower Breck v Wythenshawe Town | 4-0 | | | | | |
| Sat 05/11/22 | Burscough v Lower Breck | 0-0 | | | | | |
| Sat 12/11/22 | Lower Breck v Winsford United | 1-2 | | | | | |
| Wed 16/11/22 | AFC Liverpool v Lower Breck | 0-0 | | | | | |
| Sat 19/11/22 | Lower Breck v Wythenshawe Amateurs | 4-0 | | | | | |
| Sat 26/11/22 | Bury AFC v Lower Breck | 3-1 | | | | | |
| Wed 30/11/22 | AFC Liverpool v Lower Breck | 4-3 | | | | | |
| Mon 26/12/22 | Prestwich Heys v Lower Breck | 1-0 | | | | |  |
| Fri 06/01/23 | Lower Breck v Avro | 2-2 | | | | | |
| Thu 12/01/23 | Lower Breck v Padiham | 3-3 | | | | | |
| Tue 24/01/23 | Charnock Richard v Lower Breck | 2-1 | | | | | |
| Thu 26/01/23 | Lower Breck v Congleton Town * | 0-1 | | | | | |
| Sat 28/01/23 | Barnoldswick Town v Lower Breck | 3-3 | | | | | |
| Tue 31/01/23 | Padiham v Lower Breck | 3-1 | | | | | |
| Sat 25/02/23 | Ashton Athletic v Lower Breck | 0-1 | | | | | |
| Sat 04/03/23 | Vauxhall Motors v Lower Breck * | 6-1 | | | | | |
