| Sat 26/07/25 | Padiham v Wythenshawe | 3-0 | | | | | | |
| Tue 29/07/25 | Wythenshawe v Chadderton | 3-1 |  | | | | | |
| Sat 02/08/25 | Liversedge v Wythenshawe (CUP) * | 0-3 | |  | | | | |
| Sat 09/08/25 | Longridge Town v Wythenshawe | 0-1 | | | | | | |
| Tue 12/08/25 | Glossop North End v Wythenshawe * | 2-2 | | | | | | |
| Sat 16/08/25 | Wythenshawe v Vauxhall Motors (CUP) | - | | | | | | |
| Tue 19/08/25 | Vauxhall Motors v Wythenshawe (CUP) | 0-2 | | | | | | |
| Fri 22/08/25 | Wythenshawe v Cheadle Heath Nomads (CUP) | 3-3 | | | | | | |
| Mon 25/08/25 | Wythenshawe v FC Isle of Man | 4-0 | | | | | | |
| Sat 30/08/25 | West Auckland Town v Wythenshawe (CUP) | 3-1 | | | | | | |
| Tue 02/09/25 | Ramsbottom United v Wythenshawe | 3-0 | | | | | |  |
| Sat 06/09/25 | Wythenshawe v Barnoldswick Town | 3-0 | | | | | | |
| Tue 09/09/25 | Wythenshawe v Abbey Hey | 3-1 | | | | | | |
| Sat 13/09/25 | Wythenshawe v AFC Liverpool | 3-1 | | | | | | |
| Tue 16/09/25 | FC St Helens v Wythenshawe | 0-1 | | | | | | |
| Sat 20/09/25 | New Mills v Wythenshawe (CUP) | 0-5 | | | | | | |
| Tue 23/09/25 | Irlam v Wythenshawe | 0-2 | | | | | | |
| Sat 27/09/25 | Wythenshawe v New Mills (CUP) | 1-2 | | | | | | |
| Tue 07/10/25 | Wythenshawe v Cheadle Town | 1-3 | | | | | | |
| Sat 11/10/25 | Wythenshawe v Stockport Town | 2-1 | | | | | | |
| Tue 14/10/25 | Atherton LR v Wythenshawe | 0-1 | | | | | | |
| Sat 18/10/25 | Wythenshawe v Holker Old Boys (CUP) | 2-2 | | | | | | |
| Tue 21/10/25 | Wythenshawe v FC St Helens | 1-4 | | | | | | |
| Sat 25/10/25 | Litherland REMYCA v Wythenshawe | 1-2 | | | | | | |
| Sat 01/11/25 | Holker Old Boys v Wythenshawe (CUP) | 2-1 | | | | | | |
| Sat 08/11/25 | Abbey Hey v Wythenshawe | 1-2 | | | |  | | |
| Tue 11/11/25 | Wythenshawe v Ramsbottom United | - | | | | | | |
| Sat 15/11/25 | Wythenshawe v Euxton Villa | 2-0 | | | | | | |
| Wed 19/11/25 | Garstang v Wythenshawe (CUP) * | 0-2 | | | | | | |
| Sat 22/11/25 | Wythenshawe v City of Liverpool | 11-1 | | | | | | |
| Tue 25/11/25 | Wythenshawe v South Liverpool | 3-1 | | | | | | |
| Tue 02/12/25 | Wythenshawe v Ramsbottom United | 2-0 | | | | | | |
| Sat 06/12/25 | City of Liverpool v Wythenshawe | 1-2 | | | | | | |
| Wed 10/12/25 | AFC Liverpool v Wythenshawe | 1-5 | | | | | | |
| Fri 26/12/25 | West Didsbury & Chorlton v Wythenshawe | 0-1 | | | | | | |
| Sat 03/01/26 | South Liverpool v Wythenshawe | 1-3 | | | | | | |
| Tue 13/01/26 | Wythenshawe v Lancaster City (CUP) | 1-3 | | | | | | |
| Sat 17/01/26 | Euxton Villa v Wythenshawe | 0-3 | | | | | | |
| Tue 20/01/26 | Wythenshawe v Padiham | 6-2 | | | | | | |
| Sat 24/01/26 | Wythenshawe v Charnock Richard | 3-0 | | | | | | |
| Mon 26/01/26 | Stockport Town v Wythenshawe | 2-0 | | | | | | |
| Sat 31/01/26 | Wythenshawe v Prestwich Heys | 1-1 | | | | | | |
| Tue 03/02/26 | Prestwich Heys v Wythenshawe | 1-2 | | | | | | |
| Sat 07/02/26 | Burscough v Wythenshawe | 1-4 | | | | | | |
| Tue 10/02/26 | Wythenshawe v Pilkington | 6-1 | | | | | | |
| Tue 17/02/26 | Wythenshawe v Burscough | 3-1 | | | | | | |
| Sat 21/02/26 | FC Isle of Man v Wythenshawe | 2-1 | | | | | | |
| Sat 28/02/26 | Chadderton v Wythenshawe * | 3-2 | | | | | | |
| Sat 07/03/26 | Wythenshawe v Glossop North End | 1-1 | | | | | | |
| Tue 17/03/26 | Wythenshawe v Atherton LR * | 3-3 | | | | | | |
| Sat 21/03/26 | Charnock Richard v Wythenshawe | 2-4 | | | | | | |
