| Wed 10/08/22 | Squires Gate v Irlam * | 3-3 | | | | | |
| Sat 13/08/22 | Irlam v Vauxhall Motors * | 0-2 | | | | | |
| Sat 20/08/22 | Lower Breck v Irlam * | 0-2 | | | | | |
| Tue 23/08/22 | West Didsbury & Chorlton v Irlam * | 1-1 | | |  | | |
| Sat 27/08/22 | Irlam v Kendal Town | 3-4 | |  | | | |
| Mon 29/08/22 | Irlam v Northwich Victoria | 1-2 |  | | | |  |
| Tue 06/09/22 | Barnoldswick Town v Irlam | 3-3 | | | | | |
| Tue 13/09/22 | Irlam v Winsford United | 3-1 | | | | | |
| Sat 17/09/22 | Padiham v Irlam | 2-2 | | | | | |
| Tue 20/09/22 | Irlam v FC Isle of Man | 3-1 | | | | | |
| Sat 24/09/22 | Frickley Athletic v Irlam | 2-1 | | | | | |
| Sat 01/10/22 | Burscough v Irlam * | 2-3 | | | | | |
| Sat 08/10/22 | Litherland REMYCA v Irlam * | 0-4 | | | | | |
| Sat 15/10/22 | Irlam v Runcorn Town * | 4-0 | | | | | |
| Mon 24/10/22 | Maine Road v Irlam * | 3-0 | | | | | |
| Sat 29/10/22 | Irlam v Squires Gate * | 0-3 | | | | | |
| Sat 12/11/22 | Irlam v Avro * | 1-2 | | | | | |
| Sat 19/11/22 | Pilkington v Irlam | 1-1 | | | | | |
| Sat 03/12/22 | Winsford United v Irlam * | 2-0 | | | | | |
| Tue 06/12/22 | Wythenshawe Town v Irlam * | 1-3 | | | | | |
| Tue 20/12/22 | Northwich Victoria v Irlam | 4-1 | | | | | |
| Mon 26/12/22 | Irlam v Ashton Athletic * | 5-3 | | | | | |
| Sat 14/01/23 | Kendal Town v Irlam * | 2-2 | | | | | |
| Tue 24/01/23 | Irlam v Bury AFC | 0-2 | | | | | |
| Sat 28/01/23 | Irlam v West Didsbury & Chorlton | 1-1 | | | | | |
| Tue 31/01/23 | Irlam v Barnoldswick Town | 0-0 | | | | | |
| Sat 04/02/23 | Congleton Town v Irlam | 1-1 | | | | | |
| Sat 11/02/23 | FC Isle of Man v Irlam * | 4-1 | | | | | |
| Sat 18/02/23 | Irlam v Burscough * | 1-2 | | | | | |
| Sat 25/02/23 | Avro v Irlam * | 1-0 | | | | | |
| Tue 28/02/23 | Irlam v Prestwich Heys | 0-1 | | | | | |
| Sat 04/03/23 | Irlam v Padiham * | 0-0 | | | | | |
| Sat 11/03/23 | Longridge Town v Irlam * | 4-2 | | | | | |
