| Sat 04/10/25 | FC Isle of Man v Barnoldswick Town | 1-2 | | | | | | |
| Sat 11/10/25 | Litherland REMYCA v FC Isle of Man | 1-3 | | | |  | | |
| Sat 18/10/25 | FC Isle of Man v FC St Helens | 2-2 |  | | | | | |
| Sat 01/11/25 | FC Isle of Man v Longridge Town * | 2-2 | | | | | | |
| Tue 04/11/25 | Euxton Villa v FC Isle of Man | 3-3 | | | | | | |
| Sat 08/11/25 | FC Isle of Man v Pilkington | 1-2 | | | | | | |
| Sat 15/11/25 | FC Isle of Man v West Didsbury & Chorlton | 1-3 | | | | | | |
| Sat 22/11/25 | Longridge Town v FC Isle of Man | 2-5 | | | | | | |
| Sat 29/11/25 | Prestwich Heys v FC Isle of Man | 5-0 | | | | | | |
| Sat 06/12/25 | FC Isle of Man v Irlam | 2-2 | | | | | | |
| Sat 13/12/25 | FC Isle of Man v AFC Liverpool * | 5-0 | |  | | | | |
| Sat 20/12/25 | Glossop North End v FC Isle of Man * | 2-3 | | | | | | |
| Sat 27/12/25 | FC Isle of Man v Stockport Town * | 0-4 | | | | | | |
| Sat 10/01/26 | FC Isle of Man v Burscough | 0-1 | | | | | | |
| Wed 21/01/26 | West Didsbury & Chorlton v FC Isle of Man | 3-2 | | | | | | |
| Sat 24/01/26 | FC Isle of Man v South Liverpool | 3-2 | | | | | | |
| Wed 28/01/26 | Atherton LR v FC Isle of Man | 3-1 | | | | | | |
| Sat 31/01/26 | FC Isle of Man v Ramsbottom United | 4-4 | | | | | | |
| Sat 07/02/26 | FC Isle of Man v Euxton Villa | 1-0 | | | | | | |
| Sat 21/02/26 | FC Isle of Man v Wythenshawe | 2-1 | | | | | | |
| Sat 28/02/26 | FC Isle of Man v Abbey Hey | 2-2 | | | | | | |
| Sat 07/03/26 | FC Isle of Man v Atherton LR | 1-5 | | | | | | |
| Sat 14/03/26 | FC Isle of Man v Chadderton | 1-2 | | | | | | |
| Sat 21/03/26 | FC Isle of Man v Cheadle Town | 1-2 | | | | | | |
