There were 88 registrations between 14/3/2022 and 21/3/2022. There were also 21 deregistrations. These have been coordinated by the NWCFL League Registrations Secretary, Rob Goodwin-Davey.
| Club | Player Name | Date Registered | Reg Type | Role |
| AFC Blackpool | Joshua Woods | Tuesday 15th March 2022 | Non Contract | |
| AFC Darwen | Gary Brown | Friday 18th March 2022 | Staff | Coach |
| AFC Darwen | Kieran Wood | Friday 18th March 2022 | Staff | Coach |
| AFC Liverpool | Christopher Anderson | Friday 18th March 2022 | Non Contract | |
| AFC Liverpool | Dylan Seddon | Friday 18th March 2022 | Non Contract | |
| Alsager Town | Abidan Edwards | Saturday 19th March 2022 | Non Contract | |
| Alsager Town | Ashley Hall | Friday 18th March 2022 | Non Contract | |
| Alsager Town | Yusef Mohsin | Friday 18th March 2022 | Non Contract | |
| Ashton Town | Owen Collinge | Wednesday 16th March 2022 | Non Contract | |
| Atherton LR | Samuel Keenan | Wednesday 16th March 2022 | Non Contract | |
| Atherton LR | Aaron Knight | Monday 14th March 2022 | Non Contract | |
| Atherton LR | Ben Steer | Wednesday 16th March 2022 | Non Contract | |
| Avro | Osebi Abadaki | Monday 14th March 2022 | Non Contract | |
| Avro | Mason Dunkley | Tuesday 15th March 2022 | Non Contract | |
| Avro | Luke Horrocks | Monday 14th March 2022 | Non Contract | |
| Avro | Aaron Nuttall | Tuesday 15th March 2022 | Non Contract | |
| Brocton | Joseph Bancroft | Monday 14th March 2022 | Non Contract | |
| Brocton | Will Finlay | Friday 18th March 2022 | Non Contract | |
| Brocton | Alfie Mantle | Monday 14th March 2022 | Non Contract | |
| Campion | Fernando Moke | Saturday 19th March 2022 | Non Contract | |
| Campion | Ellis Wade | Wednesday 16th March 2022 | Non Contract | |
| Chadderton | Mauro Mendes | Friday 18th March 2022 | Non Contract | |
| Cheadle Town | Junior Omorogbe Ojo | Wednesday 16th March 2022 | Non Contract | |
| Cleator Moor Celtic | Leon Dmytrowski | Monday 14th March 2022 | Non Contract | |
| Eccleshall | Alexander Atton | Tuesday 15th March 2022 | Non Contract | |
| FC Isle of Man | Karl Clark | Tuesday 15th March 2022 | Non Contract | |
| FC Isle of Man | Shaun Kelly | Tuesday 15th March 2022 | Non Contract | |
| FC Isle of Man | Luca Moretta | Tuesday 15th March 2022 | Non Contract | |
| FC Isle of Man | Paul OBrien | Friday 18th March 2022 | Staff | Coach |
| FC Isle of Man | Max Shirley | Tuesday 15th March 2022 | Non Contract | |
| Garstang | Tyler Beck | Friday 18th March 2022 | Non Contract | |
| Garstang | Anthony Brooke | Friday 18th March 2022 | Non Contract | |
| Garstang | Christian Galindo | Friday 18th March 2022 | Non Contract | |
| Garstang | Gilberto Gomez | Friday 18th March 2022 | Non Contract | |
| Garstang | Edward Harrison | Monday 14th March 2022 | Non Contract | |
| Garstang | Alfie Hodgkinson | Friday 18th March 2022 | Non Contract | |
| Garstang | Jack Paynter | Friday 18th March 2022 | Non Contract | |
| Golcar United | Harvey Brook | Tuesday 15th March 2022 | Non Contract | |
| Golcar United | Mark Everingham | Monday 14th March 2022 | Non Contract | |
| Golcar United | Nathan Howe | Friday 18th March 2022 | Non Contract | |
| Golcar United | Nathan Tayo | Thursday 17th March 2022 | Non Contract | |
| Golcar United | Jordan Townend | Saturday 19th March 2022 | Non Contract | |
| Ilkley Town | George Gregson | Wednesday 16th March 2022 | Non Contract | |
| Litherland REMYCA | Jamie McDonald | Monday 14th March 2022 | Non Contract | |
| Lower Breck | Kian Hall | Saturday 19th March 2022 | Non Contract | |
| Lower Breck | Ben Hamlet | Tuesday 15th March 2022 | Non Contract | |
| Lower Breck | Jamie McNulty | Monday 14th March 2022 | Non Contract | |
| Lower Breck | Michael Monaghan | Wednesday 16th March 2022 | Non Contract | |
| Macclesfield | Joachim Adeoti | Friday 18th March 2022 | Non Contract | |
| Macclesfield | James Berry-McNally | Monday 14th March 2022 | Contract | |
| Macclesfield | Jelanil Blake | Monday 14th March 2022 | Non Contract | |
| Macclesfield | Harvey Smith | Monday 14th March 2022 | Non Contract | |
| Macclesfield | Ross Whiteside | Friday 18th March 2022 | Staff | Physio |
| Nelson | Sarah Ellis | Saturday 19th March 2022 | Staff | First Aider |
| Nelson | Andrew Harrison | Friday 18th March 2022 | Non Contract | |
| New Mills | Faris Khan | Monday 14th March 2022 | Non Contract | |
| Pilkington | Paul Bathgate | Tuesday 15th March 2022 | Non Contract | |
| Prestwich Heys | Charles Akande | Thursday 17th March 2022 | Non Contract | |
| Rocester | Geoff Dyche | Monday 14th March 2022 | Staff | Coach |
| Rocester | Paul Ede | Monday 14th March 2022 | Staff | Coach |
| Rocester | Thomas Evans | Monday 14th March 2022 | Non Contract | |
| Rocester | Remmiko Harper | Thursday 17th March 2022 | Work Experience | |
| Rocester | Alex Langridge | Monday 14th March 2022 | Non Contract | |
| Rocester | Charlie Milczarek-Grocott | Monday 14th March 2022 | Non Contract | |
| Sandbach United | Kieron Molloy | Friday 18th March 2022 | Non Contract | |
| Skelmersdale United | Alex Lingard | Tuesday 15th March 2022 | Non Contract | |
| Skelmersdale United | Lewis Rotherham | Tuesday 15th March 2022 | Non Contract | |
| Skelmersdale United | Edward Servuts | Friday 18th March 2022 | Non Contract | |
| South Liverpool | Leon Conway | Saturday 19th March 2022 | Non Contract | |
| South Liverpool | Philip Thompson | Saturday 19th March 2022 | Non Contract | |
| South Liverpool | Bradley Williams | Tuesday 15th March 2022 | Non Contract | |
| St Helens Town | Osagie Akhigbe-Midu | Tuesday 15th March 2022 | Non Contract | |
| St Helens Town | Joe Hampson | Tuesday 15th March 2022 | Non Contract | |
| St Helens Town | Jake Hilton | Saturday 19th March 2022 | Non Contract | |
| St Helens Town | Julian Jansen | Friday 18th March 2022 | Non Contract | |
| St Helens Town | Lennon Price | Saturday 19th March 2022 | Non Contract | |
| St Helens Town | Matthew Slevin | Friday 18th March 2022 | Non Contract | |
| St Helens Town | Carmel Tulomba | Tuesday 15th March 2022 | Non Contract | |
| Stafford Town | Beau Hudd | Thursday 17th March 2022 | Work Experience | |
| Steeton | Harvey Kavanagh | Friday 18th March 2022 | Non Contract | |
| Steeton | Kymarley Vincent | Wednesday 16th March 2022 | Non Contract | |
| Stockport Town | Jay Baisley | Monday 14th March 2022 | Non Contract | |
| Stockport Town | Jack Donlan | Monday 14th March 2022 | Non Contract | |
| Stockport Town | Oliver McFadyen | Tuesday 15th March 2022 | Non Contract | |
| Winsford United | Samuel Howell | Friday 18th March 2022 | Non Contract | |
| Wythenshawe Amateurs | JNai Butterfield-Steede | Tuesday 15th March 2022 | Non Contract | |
| Wythenshawe Amateurs | Keith Kanakulya | Friday 18th March 2022 | Non Contract | |
| Wythenshawe Town | Michael Thomas | Wednesday 16th March 2022 | Non Contract |
| Club | Player Name | Date De-Registered | Reg Type | Role |
| Abbey Hulton United | Dominic Kurasik | Saturday 19th March 2022 | Short Loan | |
| AFC Liverpool | Bradley Williams | Wednesday 16th March 2022 | Non Contract | |
| Alsager Town | Abdimajid Osman | Wednesday 16th March 2022 | Work Experience | |
| Ashton Athletic | Charles Akande | Wednesday 16th March 2022 | Non Contract | |
| Ashton Town | Jake Hilton | Saturday 19th March 2022 | Non Contract | |
| Ashton Town | Lennon Price | Saturday 19th March 2022 | Non Contract | |
| Atherton LR | Ashley Hall | Saturday 19th March 2022 | Non Contract | |
| Atherton LR | Samuel Howell | Saturday 19th March 2022 | Non Contract | |
| Atherton LR | Nathan Tayo | Saturday 19th March 2022 | Non Contract | |
| Bury AFC | Abidan Edwards | Saturday 19th March 2022 | Non Contract | |
| Charnock Richard | Samuel Keenan | Wednesday 16th March 2022 | Non Contract | |
| Irlam | Maysan Benarbia | Monday 14th March 2022 | Non Contract | |
| Rocester | Ky-mani Hunter | Tuesday 15th March 2022 | Work Experience | |
| Sandbach United | Aaron Knight | Monday 14th March 2022 | Non Contract | |
| South Liverpool | Paul Bathgate | Tuesday 15th March 2022 | Non Contract | |
| St Helens Town | Leon Conway | Saturday 19th March 2022 | Non Contract | |
| St Helens Town | Kian Hall | Saturday 19th March 2022 | Non Contract | |
| St Helens Town | Philip Thompson | Saturday 19th March 2022 | Non Contract | |
| Steeton | George Gregson | Saturday 19th March 2022 | Non Contract | |
| Steeton | Jordan Townend | Saturday 19th March 2022 | Non Contract | |
| Stockport Town | Joshua Edwards | Friday 18th March 2022 | Non Contract |
