The PlayerMatch.com Cup gets underway on Saturday with eight ties set for 3pm kick offs.
Lower Breck host Vauxhall Motors as the league leaders in the North and South Divisions collide. Motors have won six of their seven league games, while Breck have won five.
The second-placed side in the South, FC Oswestry Town, who are level on points with Vauxhall, travel to Steeton in the first round who are bottom of the North Division with four points from seven.
Shelley are third in the North and welcome one of their many divisional rivals for promotion, AFC Liverpool, who are looking for a win after back-to-back losses.
Another all-North clash sees Holker Old Boys, winless in their last four, face AFC Blackpool after they beat Redcar Athletic 2-1 in the FA Vase last time.
Two South sides clash when Abbey Hulton United look to continue their good form which has seen them win five of their last six, against an Ellesmere Rangers side who've lost all of their opening seven fixtures this campaign.
Cross division clashes include Abbey Hey v Bacup Borough, with the latter exiting the FA Vase on the weekend while the former progressed.
Cheadle Town and Cleator Moor Celtic collide in the PlayerMatch.com Cup, with Town picking up their first win of the season in the FA Vase last time out, while Celtic have won two of their seven games so far.
New Mills are winless so far this term and they host Eccleshall this Saturday after the Pershall Park outfit were knocked out of the FA Vase after extra time by Hanley Town.