| Friday 26th September 2025 | The Macron Cup 1st Rnd | ||
| 19:45 |  Ashton Athletic v FC St Helens  | Brocstedes Park | |
| 19:45 |  Ashton Town v City of Liverpool  | The Bartons Group Stadium | |
| 20:00 |  Euxton Villa v Holker Old Boys  | Jim Fowler Memorial Ground | |
| Friday 26th September 2025 The Macron Cup 1st Round |
| Ashton Athletic v FC St Helens (19:45) |
| Ashton Town v City of Liverpool (19:45) |
| Euxton Villa v Holker Old Boys (20:00) |
| Saturday 27th September 2025 The Macron Cup 1st Round |
| Abbey Hey v Stockport Georgians (15:00) |
| AFC Liverpool v South Liverpool (15:00) |
| Allscott Heath v Alsager Town (15:00) |
| Ashville v Foley Meir (15:00) |
| Bacup Borough v AFC Blackpool (15:00) |
| Cheadle Town v Glossop North End (15:00) |
| Daisy Hill v Burscough (15:00) |
| Darwen FC v Garstang (15:00) |
| Droylsden v Maine Road (15:00) |
| Eccleshall v Market Drayton Town (15:00) |
| Fulwood Amateurs v Nelson (15:00) |
| Irlam v Chadderton (15:00) |
| Litherland REMYCA v MSB Woolton (15:00) |
| Longridge Town v Barnoldswick Town (15:00) |
| Pilkington v Atherton LR (15:00) |
| Runcorn Town v Barnton (15:00) |
| Sandbach United v Haughmond (15:00) |
| Shawbury United v Wolverhampton Casuals (15:00) |
| Squires Gate v Colne (15:00) |
| Stafford Town v Cammell Laird 1907 (15:00) |
| Stockport Town v Prestwich Heys (15:00) |
| Telford Town v Wolverhampton Sporting Community (15:00) |
| Thornton Cleveleys v Steeton (15:00) |
| West Didsbury & Chorlton v Cheadle Heath Nomads (15:00) |
| Wythenshawe v New Mills (15:00) |
