| Wed 4th Aug 2021 Premier Division |
|
| Litherland REMYCA 0-1 Runcorn Town | |
| Northwich Victoria 2-2 Avro |
| Wed 4th Aug 2021 First Division North |
|
| AFC Darwen 1-5 Chadderton | |
| Garstang 2-2 St Helens Town | |
| Pilkington 3-3 Daisy Hill | |
| South Liverpool 4-2 Ashton Town |
| Wed 4th Aug 2021 First Division South |
|
| Barnton P-P FC Isle of Man | |
| Cheadle Town 2-0 Abbey Hey |
| Tue 3rd Aug 2021 Premier Division |
|
| Barnoldswick Town 2-2 Squires Gate | |
| Burscough 3-1 Ashton Athletic | |
| Irlam 0-3 Congleton Town | |
| Skelmersdale United 1-2 Longridge Town | |
| Winsford United 4-4 Macclesfield | |
| Wythenshawe Town 1-0 Padiham |
| Tue 3rd Aug 2021 First Division North |
|
| AFC Blackpool 4-0 Holker Old Boys | |
| Atherton LR 1-3 Bury AFC | |
| Bacup Borough 3-0 Ilkley Town | |
| Campion 2-3 Golcar United | |
| Nelson 3-0 Steeton |
| Tue 3rd Aug 2021 First Division South |
|
| Abbey Hulton United 2-1 Rocester | |
| Cammell Laird 1907 0-1 Ellesmere Rangers | |
| Eccleshall 3-2 Brocton | |
| New Mills 4-0 Cheadle Heath Nomads | |
| Sandbach United 6-0 St Martins | |
| Stafford Town 0-2 Alsager Town |
| Mon 2nd Aug 2021 Lancashire Challenge Trophy Final |
|
| Lancaster City 6-1 Prestwich Heys |
| Mon 2nd Aug 2021 First Division South |
|
| Maine Road 2-3 Wythenshawe Amateurs | |
| Stockport Town 0-1 West Didsbury & Chorlton |
| Sat 31st Jul 2021 Premier Division |
|
| Ashton Athletic 0-1 Wythenshawe Town | |
| Avro 3-0 Padiham | |
| Charnock Richard 5-1 Winsford United | |
| Irlam 1-0 Litherland REMYCA | |
| Longridge Town 0-1 Congleton Town | |
| Macclesfield 1-0 Burscough | |
| Prestwich Heys 0-4 Northwich Victoria | |
| Runcorn Town 1-2 Barnoldswick Town | |
| Squires Gate 0-1 Lower Breck | |
| Vauxhall Motors 1-2 AFC Liverpool |
| Sat 31st Jul 2021 First Division North |
|
| AFC Darwen 2-0 South Liverpool | |
| Ashton Town 1-2 AFC Blackpool | |
| Bacup Borough 2-2 Cleator Moor Celtic | |
| Daisy Hill 0-1 Chadderton | |
| Garstang 3-2 Campion | |
| Holker Old Boys 1-1 Golcar United | |
| Ilkley Town 2-4 Bury AFC | |
| Nelson 2-3 Pilkington | |
| St Helens Town 2-5 Atherton LR |
| Sat 31st Jul 2021 First Division South |
|
| Abbey Hey 2-2 Stockport Town | |
| Alsager Town 1-2 West Didsbury & Chorlton | |
| Barnton 1-2 Wythenshawe Amateurs | |
| Cammell Laird 1907 4-1 Cheadle Heath Nomads | |
| Cheadle Town 2-3 New Mills | |
| Maine Road 1-1 FC Isle of Man | |
| Rocester 2-1 Eccleshall | |
| Sandbach United 3-1 Brocton | |
| St Martins 2-2 Abbey Hulton United | |
| Stafford Town 3-4 Ellesmere Rangers |
Saturday KO 15:00, Midweek KO 19:45 unless stated
| Sat 7th Aug 2021 The Emirates F.A Cup Extra Preliminary Round |
| Ashton Athletic v Squires Gate |
| Athersley Recreation v Campion |
| Barnoldswick Town v Runcorn Town |
| Irlam v Albion Sports |
| Longridge Town v Northwich Victoria |
| Lower Breck v Penistone Church |
| Macclesfield v Burscough |
| Padiham v AFC Liverpool |
| Prestwich Heys v Litherland REMYCA |
| Thackley v Wythenshawe Town |
| Vauxhall Motors v Skelmersdale United |
| West Didsbury & Chorlton v Avro |
| Winsford United v Charnock Richard |
| Sat 7th Aug 2021 First Division North |
| AFC Blackpool v Cleator Moor Celtic |
| Ashton Town v Ilkley Town |
| Bury AFC v Bacup Borough |
| Chadderton v Atherton LR |
| Daisy Hill v Garstang |
| Golcar United v Nelson |
| Holker Old Boys v AFC Darwen |
| St Helens Town v Pilkington |
| Steeton v South Liverpool |
| Sat 7th Aug 2021 First Division South |
| Wythenshawe Amateurs v FC Isle of Man (14:00) |
| Abbey Hulton United v Barnton |
| Alsager Town v Maine Road |
| Brocton v Cammell Laird 1907 |
| Cheadle Heath Nomads v Abbey Hey |
| Eccleshall v Stockport Town |
| Ellesmere Rangers v Sandbach United |
| Rocester v Cheadle Town |
| St Martins v Stafford Town |
| Sun 8th Aug 2021 The Emirates F.A Cup Extra Preliminary Round |
| Emley AFC v Congleton Town (13:30) |
| Premier Division | P | GD | Pts | |
| 1 | Congleton Town | 2 | 4 | 6 |
| 2 | Wythenshawe Town | 2 | 2 | 6 |
| 3 | Northwich Victoria | 2 | 4 | 4 |
| 4 | Avro | 2 | 3 | 4 |
| 5 | Macclesfield | 2 | 1 | 4 |
| 6 | Barnoldswick Town | 2 | 1 | 4 |
| 7 | Charnock Richard | 1 | 4 | 3 |
| 8 | Burscough | 2 | 1 | 3 |
| 9 | AFC Liverpool | 1 | 1 | 3 |
| 10 | Lower Breck | 1 | 1 | 3 |
| 11 | Longridge Town | 2 | 0 | 3 |
| 12 | Runcorn Town | 2 | 0 | 3 |
| 13 | Irlam | 2 | -2 | 3 |
| 14 | Squires Gate | 2 | -1 | 1 |
| 15 | Winsford United | 2 | -4 | 1 |
| 16 | Skelmersdale United | 1 | -1 | 0 |
| 17 | Vauxhall Motors | 1 | -1 | 0 |
| 18 | Litherland REMYCA | 2 | -2 | 0 |
| 19 | Ashton Athletic | 2 | -3 | 0 |
| 20 | Prestwich Heys | 1 | -4 | 0 |
| 21 | Padiham | 2 | -4 | 0 |
| First Division North | P | GD | Pts | |
| 1 | AFC Blackpool | 2 | 5 | 6 |
| 2 | Chadderton | 2 | 5 | 6 |
| 3 | Bury AFC | 2 | 4 | 6 |
| 4 | Bacup Borough | 2 | 3 | 4 |
| 5 | Pilkington | 2 | 1 | 4 |
| 6 | Garstang | 2 | 1 | 4 |
| 7 | Golcar United | 2 | 1 | 4 |
| 8 | Nelson | 2 | 2 | 3 |
| 9 | Atherton LR | 2 | 1 | 3 |
| 10 | South Liverpool | 2 | 0 | 3 |
| 11 | AFC Darwen | 2 | -2 | 3 |
| 12 | Cleator Moor Celtic | 1 | 0 | 1 |
| 13 | Daisy Hill | 2 | -1 | 1 |
| 14 | St Helens Town | 2 | -3 | 1 |
| 15 | Holker Old Boys | 2 | -4 | 1 |
| 16 | Campion | 2 | -2 | 0 |
| 17 | Ashton Town | 2 | -3 | 0 |
| 18 | Steeton | 1 | -3 | 0 |
| 19 | Ilkley Town | 2 | -5 | 0 |
| First Division South | P | GD | Pts | |
| 1 | Sandbach United | 2 | 8 | 6 |
| 2 | New Mills | 2 | 5 | 6 |
| 3 | Ellesmere Rangers | 2 | 2 | 6 |
| 4 | Wythenshawe Amateurs | 2 | 2 | 6 |
| 5 | West Didsbury & Chorlton | 2 | 2 | 6 |
| 6 | Abbey Hulton United | 2 | 1 | 4 |
| 7 | Cammell Laird 1907 | 2 | 2 | 3 |
| 8 | Cheadle Town | 2 | 1 | 3 |
| 9 | Alsager Town | 2 | 1 | 3 |
| 10 | Eccleshall | 2 | 0 | 3 |
| 11 | Rocester | 2 | 0 | 3 |
| 12 | FC Isle of Man | 1 | 0 | 1 |
| 13 | Maine Road | 2 | -1 | 1 |
| 14 | Stockport Town | 2 | -1 | 1 |
| 15 | Abbey Hey | 2 | -2 | 1 |
| 16 | St Martins | 2 | -6 | 1 |
| 17 | Barnton | 1 | -1 | 0 |
| 18 | Brocton | 2 | -3 | 0 |
| 19 | Stafford Town | 2 | -3 | 0 |
| 20 | Cheadle Heath Nomads | 2 | -7 | 0 |
Tables correct as at Tue 3rd Aug 2021
