| Tue 26th Oct 2021 Premier Division |
|
| Charnock Richard 2-1 Squires Gate | |
| Longridge Town 2-2 Runcorn Town | |
| Prestwich Heys 1-0 AFC Liverpool | |
| Skelmersdale United 2-2 Winsford United | |
| Wythenshawe Town 1-2 Barnoldswick Town |
| Tue 26th Oct 2021 First Division North |
|
| Atherton LR 0-3 Nelson | |
| Golcar United 4-0 South Liverpool | |
| Holker Old Boys 2-1 Daisy Hill |
| Tue 26th Oct 2021 First Division South |
|
| Wythenshawe Amateurs 0-4 Abbey Hey |
| Tue 26th Oct 2021 Cheshire Senior Cup 1st Round |
|
| Congleton Town 0-3 Stalybridge Celtic | |
| Crewe Alexandra P-P Sandbach United |
| Sun 24th Oct 2021 The Buildbase FA Vase 1st Round |
|
| AFC Liverpool 2-1 Newton Aycliffe |
| Sat 23rd Oct 2021 The Buildbase FA Vase 1st Round |
||||
| Abbey Hey 6-0 Parkgate | ||||
| Barton Town 3-1 Cleator Moor Celtic | ||||
| Billingham Synthonia 4-2 FC Isle of Man | ||||
| Burscough 1-1 Garforth Town | ||||
| (Burscough won 6-5 on pens) | ||||
| Consett 2-1 Atherton LR | ||||
| Emley AFC 4-1 Longridge Town | ||||
| Eynesbury Rovers 1-2 Sandbach United | ||||
| Holker Old Boys 3-1 Skelmersdale United | ||||
| Newcastle Benfield 3-2 Golcar United | ||||
| Pilkington 7-3 West Allotment Celtic | ||||
| Prestwich Heys 4-2 Penrith | ||||
| Seaham Red Star 0-0 Wythenshawe Town | ||||
| (Wythenshawe Town won 4-3 on pens) | ||||
| Sunderland Ryhope CW 1-2 Bury AFC | ||||
| Thornaby 4-0 South Liverpool | ||||
| Vauxhall Motors 1-2 North Shields | ||||
| Sat 23rd Oct 2021 Premier Division |
|
| Charnock Richard 4-3 Congleton Town | |
| Irlam 1-4 Lower Breck | |
| Litherland REMYCA 1-2 Avro | |
| Macclesfield 3-0 Padiham | |
| Runcorn Town 0-3 Winsford United |
| Sat 23rd Oct 2021 First Division North |
|
| Chadderton 0-3 Steeton | |
| Garstang 1-1 Ashton Town | |
| Nelson P-P AFC Darwen |
| Sat 23rd Oct 2021 First Division South |
|
| Brocton 3-3 Cheadle Town | |
| Cheadle Heath Nomads 3-0 St Martins | |
| Eccleshall 0-1 Abbey Hulton United | |
| Ellesmere Rangers 3-3 Alsager Town | |
| Maine Road 5-0 Cammell Laird 1907 | |
| New Mills 5-1 Stafford Town | |
| Rocester 0-2 West Didsbury & Chorlton | |
| Stockport Town 1-1 Barnton |
| Wed 27th Oct 2021 First Division North |
| Garstang v Cleator Moor |
| Pilkington v Bury AFC |
| Wed 27th Oct 2021 First Division South |
| Cheadle Town v FC Isle of Man |
| Wed 27th Oct 2021 Cheshire Senior Cup 1st Rnd |
| Northwich Vics v Tranmere Rovers |
Saturday KO 15:00, Midweek KO 19:45 unless stated
| Fri 29th Oct 2021 Premier Division |
| AFC Liverpool v Wythenshawe Town (20:00) |
| Lower Breck v Macclesfield (20:00) |
| Sat 30th Oct 2021 Premier Division |
| Ashton Athletic v Irlam |
| Avro v Runcorn Town |
| Barnoldswick Town v Skelmersdale United |
| Congleton Town v Winsford United |
| Litherland REMYCA v Padiham |
| Prestwich Heys v Longridge Town |
| Squires Gate v Northwich Victoria |
| Vauxhall Motors v Burscough |
| Sat 30th Oct 2021 First Division North |
| AFC Darwen v AFC Blackpool |
| Ashton Town v Campion |
| Bury AFC P-P Chadderton |
| (Postponed due to Radcliffe in FA Trophy) |
| Cleator Moor Celtic v Atherton LR |
| Daisy Hill v Ilkley Town |
| Golcar United v St Helens Town |
| Nelson v Bacup Borough |
| Pilkington v Garstang |
| Steeton v Holker Old Boys |
| Sat 30th Oct 2021 First Division South |
| Alsager Town v Eccleshall |
| Barnton v St Martins |
| Cammell Laird 1907 v Stockport Town |
| Cheadle Town v Sandbach United |
| Ellesmere Rangers v Abbey Hulton United |
| Maine Road v Cheadle Heath Nomads |
| Rocester v New Mills |
| Stafford Town v Abbey Hey |
| West Didsbury & Chorlton v Wythenshawe Amateurs |
| FC Isle of Man v Brocton (18:30) |
| Premier Division | P | GD | Pts | |
| 1 | Macclesfield | 16 | 15 | 36 |
| 2 | Skelmersdale United | 16 | 17 | 31 |
| 3 | Charnock Richard | 16 | 18 | 30 |
| 4 | Irlam | 17 | 5 | 29 |
| 5 | Avro | 16 | 3 | 27 |
| 6 | Congleton Town | 17 | 10 | 25 |
| 7 | Wythenshawe Town | 16 | 10 | 25 |
| 8 | Barnoldswick Town | 16 | 6 | 25 |
| 9 | Longridge Town | 16 | 6 | 25 |
| 10 | Lower Breck | 16 | 2 | 25 |
| 11 | Burscough | 15 | 6 | 24 |
| 12 | Northwich Victoria | 15 | 5 | 24 |
| 13 | Vauxhall Motors | 16 | -5 | 24 |
| 14 | AFC Liverpool | 16 | -5 | 21 |
| 15 | Prestwich Heys | 17 | -11 | 19 |
| 16 | Winsford United | 17 | -13 | 18 |
| 17 | Squires Gate | 16 | -4 | 17 |
| 18 | Ashton Athletic | 16 | -13 | 17 |
| 19 | Runcorn Town | 17 | -10 | 15 |
| 20 | Padiham | 16 | -7 | 13 |
| 21 | Litherland REMYCA | 17 | -35 | 6 |
| First Division North | P | GD | Pts | |
| 1 | Bury AFC | 13 | 24 | 33 |
| 2 | Golcar United | 14 | 19 | 33 |
| 3 | Holker Old Boys | 14 | 10 | 32 |
| 4 | Pilkington | 13 | 5 | 26 |
| 5 | AFC Blackpool | 14 | 6 | 24 |
| 6 | Chadderton | 14 | 2 | 24 |
| 7 | Bacup Borough | 14 | 11 | 22 |
| 8 | Nelson | 15 | -1 | 19 |
| 9 | South Liverpool | 15 | -5 | 19 |
| 10 | Campion | 15 | 8 | 18 |
| 11 | Steeton | 15 | 2 | 18 |
| 12 | Ashton Town | 14 | -6 | 18 |
| 13 | Garstang | 13 | 3 | 17 |
| 14 | Atherton LR | 14 | -6 | 17 |
| 15 | Ilkley Town | 15 | -3 | 16 |
| 16 | Daisy Hill | 14 | -3 | 14 |
| 17 | AFC Darwen | 13 | -14 | 12 |
| 18 | Cleator Moor Celtic * | 12 | -8 | 5 |
| 19 | St Helens Town | 15 | -44 | 3 |
| First Division South | P | GD | Pts | |
| 1 | West Didsbury & Chorlton | 15 | 30 | 39 |
| 2 | New Mills | 15 | 28 | 38 |
| 3 | Abbey Hey | 15 | 32 | 37 |
| 4 | Wythenshawe Amateurs | 16 | 22 | 32 |
| 5 | Sandbach United | 15 | 18 | 29 |
| 6 | Cheadle Town | 14 | 14 | 26 |
| 7 | FC Isle of Man | 13 | 20 | 25 |
| 8 | Cheadle Heath Nomads | 16 | 2 | 25 |
| 9 | Stafford Town | 16 | -8 | 24 |
| 10 | Ellesmere Rangers | 15 | 10 | 23 |
| 11 | Abbey Hulton United | 16 | -9 | 22 |
| 12 | Maine Road | 15 | 8 | 19 |
| 13 | Cammell Laird 1907 | 15 | -13 | 17 |
| 14 | Barnton | 15 | -15 | 16 |
| 15 | Stockport Town | 16 | -1 | 14 |
| 16 | Alsager Town | 15 | -14 | 14 |
| 17 | Brocton | 16 | -26 | 14 |
| 18 | Rocester | 15 | -18 | 10 |
| 19 | Eccleshall | 16 | -21 | 10 |
| 20 | St Martins | 15 | -59 | 2 |
Tables correct as at Sat 23rd Oct 2021
