First placed Vauxhall Motors travel to second in the table FC Oswestry Town in a huge clash on Bank Holiday Monday in the First Division South.
Only Vauxhall Motors have their 100% record still intact after they won 2-0 against Alsager Town, while Sandbach United demolished FC Oswestry 4-0 on the same day.
It's been a sorry start to the campaign for Ellesmere Rangers who have conceded 25 goals in their opening six games, but they look to turn their fortunes around when they welcome an Abbey Hulton United side who have won three and lost three to open their campaign.
New Mills have played two games less than most of the other sides in the division, but still look for their first points of the season when Eccleshall come to Church Lane off the back of scoring 13 goals in their last two.
Sandbach have beaten teams above them like Oswestry and St Martins in recent weeks, and will be aiming for much of the same against a Stone Old Alleynians team yet to be defeated in league action this season.
West Didsbury & Chorlton occupy third place in the table and they'll travel to Barnton in an attempt to keep pace with the frontrunners. Barnton beat Cheadle Town on Friday evening.
Wythenshawe Amateurs ran away 1-0 winners on their trip to Abbey Hulton United on Saturday, and the team in fifth are away at Maine Road who beat Cheadle Heath Nomads 4-1 last time out.
Nomads will be at home when they face an Alsager Town side who have won one league game in their opening six.
After drawing 3-3 despite being 2-0 up, Cammell Laird 1907 are once again at home and face St Martins, the side in 9th place after losing their last three.
Wythenshawe Town were the team who drew with Cammell Laird, and they are away at Cheadle Town who are searching for their first league victory of the campaign.
16th place Abbey Hey, fresh off a 4-1 defeat to Eccleshall, face 15th place Stockport Town after they picked up a 3-2 win away at St Martins in their last fixture.